Traditional Uses

• External application:
  
  • varicose veins
  • leg ulcers
  • hemorrhoids
• Taken internally:
  • strengthening and toning effect on the circulatory system

Mode of Action

• Contains esculin (a coumarin derivative) which:
  • reduces exudate (oozing) and edema (swelling) in surrounding tissue
  • increases venous tone
• Increases plasma antithrombic activity (anticoagulant)

Drug Interactions

• None reported

Cautions

• Esculin is found in some prescription suppositories and creams for treating hemorrhoids. Do not use this product and those medicines at the same time
• Avoid in patients with kidney disease
• May cause upset stomach
• Keep out of reach of children

Recommended Dose

• 500-mg extract daily. (Dose may vary from brand to brand)

References

• Blumenthal, 1998; Chandler, 1993; Duke, 1997; Tyler, 1993