Traditional Uses

• Immune system enhancer
• Antioxidant
• Venous and capillary disorders
• Diabetic retinopathy
• Macular degeneration
• May help to prevent atherosclerosis (hardening of the arteries)
  and cancer

Mode of Action

• Grape seeds contain flavonols, in particular proanthocyanidins which
  • increase intracellular vitamin C
  • decrease capillary permeability
  • decrease collagen destruction
  • scavenge free radicals
  • delay onset of lipid peroxidation

Drug Interactions

• No known drug interactions

Cautions

• None reported

Recommended Dose

• 50-300 mg once a day containing 95% proanthocyanidins. (Dose may vary from brand to brand)

References

• Lewis, 1977