Traditional Uses

• Assists in the prevention and relief of migraine headaches
• Rheumatoid arthritis

Mode of Action

• Contains sesquinterpene lactones including parthenolide which inhibit the release of the hormone serotonin, which is believed to trigger migraines
• They also suppress the production of inflammation causing prostaglandins.

Drug Interactions

• May increase the effects of anticoagulant therapy. Do not take if taking warfarin, heparin or any other blood thinning drugs

Cautions

• Sensitive individuals may develop contact dermatitis (skin rash) with prolonged use
• Do not take during pregnancy or while breast feeding
• Do not give to children under the age of two
• May cause upset stomach
• May cause mouth ulceration in sensitive people
• People who stop taking feverfew may suffer from Post-feverfew syndrome including nervousness, tension, fatigue and joint-ache

Recommended Dose

• 140 mg once a day containing a minimum 0.2% parthenolide (for 280 mcg parthenolide).
• Do not exceed 1000 mcg of parthenolide per day. (Dose may vary from brand to brand)

References

• Chevallier, 1996; Hoffman, 1990; Johnson, 1997; Newall, 1996; Tyler, 1993; Tyler, 1994; Weiner, 1994